HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[2-oxofuran-4(5H)-yloxy]-2H-1-benzopyran-6-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Sdz pco 400 | HCID 129348 | — |
| Reactant | Tetronic acid | HCID 521261 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-[2-oxofuran-4(5H)-yloxy]-2H-1-benzopyran-6-carbonitrile | HCID 14301308 | — |
Reaction Steps
601 mg of tetronic acid and 1.01 g of the epoxide of example 1 are reacted analogously to example 6 with 180 mg of sodium hydride (80%) and 747 mg of borontrifluoride-diethyletherate in tetrahydrofurane. Usual work up yields white crystalls of the title compound. m.p. 111°-114° C. (dichloromethane/ether)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05071871 |
| Source dataset | uspto-grants-1991_12 |
| ORD ID | ord-c790d8eee90d47818a0780194ea3da25 |
| Source note | uspto-grants-1991_12 |