Water → HCID 70230009, compound

Participants

Reaction Steps

(R)-1-[2-[[2-(2-Chlorophenyl)-2-(2-methylphenyl)ethenyl]oxy]ethyl]-3-piperidine carboxylic acid ethyl ester (4.1 g, 0.0096 mol) (prepared as described in Method D) was dissolved in ethanol (100 ml) and 18N sodium hydroxide solution (10 ml) was introduced. After stirring the solution at room temperature for 1 h water (500 ml) was added, and the solution was washed with diethyl ether (2×100 ml). The pH of the aqueous phase was adjusted to 1 using 2N hydrochloric acid solution and extracted with dichloromethane (4×200 ml). The combined extracts were dried (MgSO4), evaporated and the residue was crystallized from toluene/trace methanol to provide the title compound (3.47 g, 87%) as a white crystalline solid, m.p. 231°-234°.

Provenance & Evidence