HCID 19086875, compound → HCID 19086858, compound

HRID 1460693Notes

Reaction equation

HRID 1460693 reaction equation
C(O[N:5]=[C:6]1[CH2:11][CH2:10][N:9]([C:12]([C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[NH:20][C:19](=[O:24])[CH2:18][CH2:17]3)=[O:13])[CH2:8][CH2:7]1)(=O)C>C(O)(=O)C.[Pt]=O>[NH2:5][CH:6]1[CH2:11][CH2:10][N:9]([C:12]([C:14]2[CH:15]=[C:16]3[C:21](=[CH:22][CH:23]=2)[NH:20][C:19](=[O:24])[CH2:18][CH2:17]3)=[O:13])[CH2:8][CH2:7]1

Participants

4

Reactant 1

HCID 19086875HCID 19086875, compound

Product 1

HCID 19086858HCID 19086858, compound

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 176Acetic AcidSolvent

Procedure

10 Grams of 6-(4-acetyloxyimino-1-piperidylcarbonyl)-3,4-dihydrocarbostyril and 0.5 g of platinum oxide were dispersed in 150 ml of acetic acid, then the mixture was catalytically reduced at room temperature under normal pressure. The catalyst was removed by filtration, then the filtrate was concentrated under reduced pressure by evaporating the solvent, the residue thus obtained was purified by means of a silica gel column chromatography (eluent: dichloromethane:methanol =10:1) to yield 3 g of 6-(4-amino-1-piperidylcarbonyl)-3,4-dihydrocarbostyril.

Workup

  1. customwas catalytically reduced at room temperature under normal pressure
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate was concentrated under reduced pressure
  4. customby evaporating the solvent
  5. customthe residue thus obtained
  6. customwas purified by means of a silica gel column chromatography (eluent: dichloromethane:methanol =10:1)

Sources & evidence

ORD record
ord-c4e781fb2ee44269b3ae9ab8acef03f4
Source dataset
uspto-grants-1991_12
Patent number
US05071856

Reaction notes

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