反应详情

To a solution of 3,4,5-triphenyl-1H-pyrazole-1-decanal (2.42 g, 5.4 mmol) in acetone (47 mL maintained at 0° C. was added dropwise 1.75 mL (7 mmol) of 8N Jones reagent. The ice water was removed and the mixture stirred for 48 minutes before being diluted with acetone, filtered through diatomaceous earth and concentrated. The residual oil was chromatographed on a column of silica gel using a mixture of hexane and ethyl acetate (13:7) as eluent to afford 3,4,5-triphenyl-1H-pyrazole-1-decanoic acid hydrate (2.46 g, 81%) as an oil. MS(CI): m/e=467 (MH+).

1. customThe ice water was removed
2. additionbefore being diluted with acetone
3. filtrationfiltered through diatomaceous earth
4. concentrationconcentrated
5. customThe residual oil was chromatographed on a column of silica gel using
6. additiona mixture of hexane and ethyl acetate (13:7) as eluent