Ethylmorpholine → HCID 14724727, compound

Participants

Reaction Conditions

Reaction Steps

4.71 ml of N-ethylmorpholine and 7.98 g of DCC are added at 0° C. to a solution of 10.69 g of Z-D-Phe-OH, 14.5 g of H-D-Phe-Ser(tBu)-OtBu.HCl and 4.89 g of HOBt in 150 ml of dimethylformamide. The mixture is left to stir at 0° C. for 1 hour and to stand at room temperature overnight. The precipitate is filtered off with suction, and the filtrate is concentrated. The residue is partitioned between ethyl acetate and water. The ethyl acetate phase is extracted by shaking successively with saturated NaHCO3 solution, KHSO4 /K2SO4 solution and water, dried over Na2SO4 and concentrated. The oil crystallizes from isopropanol/petroleum ether.

Provenance & Evidence