L-Methionine → 4'-Hydroxyacetophenone

Participants

Reaction Steps

In this connection, the demethylation of compounds of relatively simple structure by means of a couple sulfonic acid/derivative of the sulfide type, for instance methanesulfonic acid or trifluoromethanesulfonic acid and methionine, is known. This method is reported in particular in J. C. S. Perkin I. pp. 2288-2289 (1977). The results obtained with this method are usually very varied (yield of demethylated compounds varies from 30 to 90%) and may be poor. This is the case for p-methoxyacetophenone: no reaction is recorded at 20° C. and only 30% yield of p-hydroxyacetophenone is obtained after 72 hours at 60° C.

Provenance & Evidence