HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Benzylamino)acetic acid → Ethyl 1-benzylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Benzylamino)acetic acid | HCID 86965 | — |
| Reactant | Ethyl allyl(2-oxoethyl)carbamate | HCID 11084330 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl 1-benzylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate | HCID 11086974 | — |
Reaction Steps
42.8 g (0.25 mol) of ethyl N-allyl-N-(2-oxoethyl) -carbamate are heated under reflux overnight with 41.3 g (0.25 mol) of N-benzylglycine in 750 ml of toluene. The mixture is concentrated and the residue is distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05071999 |
| Source dataset | uspto-grants-1991_12 |
| ORD ID | ord-ebc0674da76c498f8182c2ec2015f027 |
| Source note | uspto-grants-1991_12 |