HCID 19100956, compound → HCID 19100947, compound

HRID 1460759Notes

Reaction equation

HRID 1460759 reaction equation
C([N:8]1[CH:15]([CH3:16])[CH2:14][CH:13]2[CH:9]1[CH2:10][N:11]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12]2)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:16][CH:15]1[CH2:14][CH:13]2[CH:9]([CH2:10][N:11]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:12]2)[NH:8]1

Participants

4

Reactant 1

HCID 19100956HCID 19100956, compound

Product 1

HCID 19100947HCID 19100947, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

32 g (0.11 mol) of ethyl 2-benzyl-3-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate in 560 ml of ethanol are hydrogenated at 100° C. and 100 bar on 4.5 g of palladium-active carbon. The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.

Workup

  1. customare hydrogenated at 100° C.
  2. filtrationThe catalyst is filtered off with suction
  3. concentrationthe filtrate is concentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-399f23112d3a4eea9af748c1fbf792a4
Source dataset
uspto-grants-1991_12
Patent number
US05071999

Reaction notes

Loading…