Formic Acid → HCID 19738500, compound

HRID 1460770Notes

Reaction equation

HRID 1460770 reaction equation
[Cl:1][C:2](=[CH2:16])[CH2:3][N:4]([CH2:10][CH:11](OC)[O:12]C)[C:5](=[O:9])[O:6][CH2:7][CH3:8].C(O)=O.[Cl-].[Na+]>O>[Cl:1][C:2](=[CH2:16])[CH2:3][N:4]([CH2:10][CH:11]=[O:12])[C:5](=[O:9])[O:6][CH2:7][CH3:8]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 5234Sodium ChlorideHCID 19738531HCID 19738531, compound

Product 1

HCID 19738500HCID 19738500, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

151 g (0.6 mol) of ethyl N-(2-chloroallyl)-N -(2,2-dimethoxyethyl)-carbamate are heated under reflux for 3 hours with 60 ml of formic acid in 1.2 1 of water. The mixture is saturated with sodium chloride, and the aqueous phase is separated off and extracted twice with 300 ml of methylene chloride each time. The organic phases are washed with saturated sodium hydrogen carbonate solution until neutral, dried over magnesium sulphate and concentrated, and the residue is distilled.

Workup

  1. customthe aqueous phase is separated off
  2. extractionextracted twice with 300 ml of methylene chloride each time
  3. washThe organic phases are washed with saturated sodium hydrogen carbonate solution until neutral,
  4. dry with materialdried over magnesium sulphate
  5. concentrationconcentrated
  6. distillationthe residue is distilled

Sources & evidence

ORD record
ord-48cd5603b4eb4bc1bb61f700f4785181
Source dataset
uspto-grants-1991_12
Patent number
US05071999

Reaction notes

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