N-Methyl-L-Alanine → HCID 19100959, compound

HRID 1460773Notes

Reaction equation

HRID 1460773 reaction equation
[Cl:1][C:2](=[CH2:13])[CH2:3][N:4]([CH2:10][CH:11]=O)[C:5](=[O:9])[O:6][CH2:7][CH3:8].[CH3:14][NH:15][C@H:16](C(O)=O)[CH3:17]>C1(C)C=CC=CC=1>[Cl:1][C:2]12[CH2:3][N:4]([C:5]([O:6][CH2:7][CH3:8])=[O:9])[CH2:10][CH:11]1[N:15]([CH3:14])[CH:16]([CH3:17])[CH2:13]2

Participants

4

Reactant 2

HCID 5288725N-Methyl-L-AlanineHCID 19738500HCID 19738500, compound

Product 1

HCID 19100959HCID 19100959, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

10.3 g (50 mmol) of ethyl N-(2-chloroallyl)-N-(2 -oxoethyl)-carbamate are heated under reflux overnight with 5.2 g (50.5 mmol) of N-methylalanine in 200 ml of toluene. The mixture is concentrated and the residue is distilled.

Workup

  1. concentrationThe mixture is concentrated
  2. distillationthe residue is distilled

Sources & evidence

ORD record
ord-412b4ed5d2e74f529c8dd7540f8bfa5e
Source dataset
uspto-grants-1991_12
Patent number
US05071999

Reaction notes

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