HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → Ethyl 1,4-diazatricyclo [6.2.0.02,6]decane-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Azetidinecarboxylic Acid | HCID 17288 | — |
| Reactant | Ethyl allyl(2-oxoethyl)carbamate | HCID 11084330 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Ethyl 1,4-diazatricyclo [6.2.0.02,6]decane-4-carboxylate | HCID 54190177 | — |
Reaction Steps
17.1 g (0.1 mol) of ethyl N-allyl-N-(2-oxoethyl) -carbamate are heated under reflux overnight in a water separator with 10 g (0.1 mol) of azetidine-2-carboxylic acid in 200 ml of toluene. Unreacted amino acid is filtered off with suction, the filtrate is concentrated and the residue is distilled.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05071999 |
| Source dataset | uspto-grants-1991_12 |
| ORD ID | ord-2faa50c541fd4399b611f0b5861af91e |
| Source note | uspto-grants-1991_12 |