HCID 19100963, compound → HCID 22924370, compound

HRID 1460794Notes

Reaction equation

HRID 1460794 reaction equation
C([N:8]1[CH2:15][CH:14]([CH3:16])[CH:13]2[CH:9]1[CH2:10][NH:11][CH2:12]2)C1C=CC=CC=1>CO.[Pd]>[CH3:16][CH:14]1[CH:13]2[CH:9]([CH2:10][NH:11][CH2:12]2)[NH:8][CH2:15]1

Participants

4

Reactant 1

HCID 19100963HCID 19100963, compound

Product 1

HCID 22924370HCID 22924370, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

4.1 g (19 mmol) of 2-benzyl-4-methyl-2,7-diazabicyclo[3.3.0]octane in 80 ml of methanol are hydrogenated at 100° C. and 100 bar on 1 g of palladium-active carbon (10% Pd). The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.

Workup

  1. customare hydrogenated at 100° C.
  2. filtrationThe catalyst is filtered off with suction
  3. concentrationthe filtrate is concentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-2404b31d95e5402a943b6ceb2745d952
Source dataset
uspto-grants-1991_12
Patent number
US05071999

Reaction notes

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