Formic Acid → HCID 19738514, compound

HRID 1460796Notes

Reaction equation

HRID 1460796 reaction equation
[F:1][CH2:2][C:3](=[CH2:17])[CH2:4][N:5]([CH2:11][CH:12](OC)[O:13]C)[C:6](=[O:10])[O:7][CH2:8][CH3:9].C(O)=O.[Cl-].[Na+]>O>[F:1][CH2:2][C:3](=[CH2:17])[CH2:4][N:5]([CH2:11][CH:12]=[O:13])[C:6](=[O:10])[O:7][CH2:8][CH3:9]

Participants

5

Reactant 3

HCID 284Formic AcidHCID 5234Sodium ChlorideHCID 19738525HCID 19738525, compound

Product 1

HCID 19738514HCID 19738514, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

25 g (0.1 mol) of ethyl N-(2-fluoromethylallyl) -N-(2,2-dimethoxyethyl)carbamate are heated under reflux for two hours with 5 g of formic acid in 100 ml of water. The mixture is saturated with sodium chloride and extracted with methylene chloride, and the organic phases are washed with sodium hydrogen carbonate solution until neutral. They are dried over magnesium sulphate and concentrated, and the residue is distilled.

Workup

  1. extractionextracted with methylene chloride
  2. washthe organic phases are washed with sodium hydrogen carbonate solution until neutral
  3. dry with materialThey are dried over magnesium sulphate
  4. concentrationconcentrated
  5. distillationthe residue is distilled

Sources & evidence

ORD record
ord-2f193503fa9d4074a134bbec8aa0361d
Source dataset
uspto-grants-1991_12
Patent number
US05071999

Reaction notes

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