HCID 19100950, compound → HCID 19100969, compound

HRID 1460806Notes

Reaction equation

HRID 1460806 reaction equation
C([N:8]1[CH2:15][CH2:14][CH:13]2[CH:9]1[CH2:10][N:11]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:12]2[CH3:16])C1C=CC=CC=1>C(O)C.[Pd]>[CH3:16][CH:12]1[N:11]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH2:10][CH:9]2[CH:13]1[CH2:14][CH2:15][NH:8]2

Participants

4

Reactant 1

HCID 19100950HCID 19100950, compound

Product 1

HCID 19100969HCID 19100969, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

13 g (44.9 mmol) of ethyl 2-benzyl-6-methyl-2,7-diazabicyclo[3.3.0]octane-7-carboxylate in 150 ml of ethanol are hydrogenated ar 100° C. and 100 bar on 2 g of palladium-active carbon (10% Pd). The catalyst is filtered off, the filtrate is concentrated and the residue is distilled.

Workup

  1. customare hydrogenated ar 100° C.
  2. filtrationThe catalyst is filtered off
  3. concentrationthe filtrate is concentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-a26fca36779e4577afd08229d8687683
Source dataset
uspto-grants-1991_12
Patent number
US05071999

Reaction notes

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