HCID 19100964, compound → HCID 16228902, compound

HRID 1460808Notes

Reaction equation

HRID 1460808 reaction equation
C([N:8]1[CH:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:14][CH:13]2[CH:9]1[CH2:10][N:11]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:12]2)C1C=CC=CC=1>[Pd].C(O)C>[CH:9]12[CH2:10][N:11]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:12][CH:13]1[CH2:14][CH:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[NH:8]2

Participants

4

Reactant 1

HCID 19100964HCID 19100964, compound

Product 1

HCID 16228902HCID 16228902, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

96.5 g (0.279 mol) of diethyl 2-benzyl-2,7-diazabicyclo[3.3.0]octane-3,7-dicarboxylate in 1 1 of ethanol are hydrogenated at 100 C and 100 bar on 5 g of palladium-active carbon (10% Pd). The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.

Workup

  1. filtrationThe catalyst is filtered off with suction
  2. concentrationthe filtrate is concentrated
  3. distillationthe residue is distilled

Sources & evidence

ORD record
ord-533ec916633345caa16f14b322816b9e
Source dataset
uspto-grants-1991_12
Patent number
US05071999

Reaction notes

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