Water → 4-chloro-N-hexadecyl-N-methyl-3-nitrobenzenesulfonamide

Participants

Reaction Steps

In 640 ml of acetone was dissolved 170 g of 4-chloro-3-nitro-N-hexadecylbenzenesulfonamide prepared in the above step and after adding thereto 79 g of potassium carbonate, 6 ml of polyethylene glycol (average molecular weight: 400), and 71 g of dimethylsulfuric acid, the mixture was refluxed for 5 hours. To the reaction mixture thus obtained was added 240 ml of acetone and after adding dropwise 870 ml or water to the mixture at 40° C., the resultant mixture was cooled to room temperature, whereby crystals deposited. The crystals were recovered by filtration, washed with water and then methanol, and dried to provide 169 g of the above-described compound with a yield of 97%. The melting point thereof was 74° C. to 75° C.

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