Dimethyl Sulfoxide → HCID 14324515, compound

Participants

Reaction Steps

After mixing 400 g of ethyl 4-chloro-3-nitrobenzoate, 1.2 liters of dimethyl sulfoxide, 270 g of 5-methyl-3-hydroxyisoxazole, and 292 g of potassium carbonate, the reaction was performed for 10 hours at 60° C. After the reaction was over, the reaction mixture was cooled and poured into water. Crystals thus deposited were recovered by filtration and recrystallized from ethyl acetate to provide 300.1 g of the above-described compound with a yield of 59.0%. The melting point thereof was 122° C. to 123° C.

Provenance & Evidence