HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3,5-Dichloro-2,4-difluorobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3,5-Dichloro-2,4-difluorobenzoyl fluoride | HCID 5463764 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3,5-Dichloro-2,4-difluorobenzamide | HCID 13565027 | 90% |
Reaction Steps
620 ml of concentrated aqueous ammonia solution and 600 ml of water are initially introduced, 458 g (2 moles) of 3,5-dichloro-2,4-difluorobenzoyl fluoride are added dropwise at 40°-50°, and then the mixture is stirred at 50° for 30 minutes. The precipitate is filtered off with suction, washed with water and dried. 408 g (90% of theory) of 3,5-dichloro-2,4-difluorobenzamide of melting point 163°-164° are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05072038 |
| Source dataset | uspto-grants-1991_12 |
| ORD ID | ord-0676c9de1d9f4f1d9a0eeb9394275311 |
| Source note | uspto-grants-1991_12 |