Dimethylamine → HCID 11735930, compound

Participants

Reaction Steps

To a solution of 3-acetamidophenol (15.25 g, 101 mmol) in 40% dimethylamine (13.8 ml, 122 mmol) and 13 ml of methanol, was added 37% formalin (8.3 ml, 101 mmol). The reaction mixture was placed in an ice bath just after the precipitate formed (about 15-30 minutes). The white precipitate was filtered after 10-30 minutes, washed with cold water, and air-dried to give 13.7 g (65%) of 5-acetamido-2-[(dimethylamino)methyl]phenol, m.p. 133°-135° C.

Provenance & Evidence