Sulfate Ion → HCID 14745954, compound

Participants

Reaction Steps

In a flask replaced with nitrogen, 72 mg (1.9 mmol) of lithium aluminum hydride and 2 ml of dry diethyl ether were placed and cooled with ice, and a solution of 0.4 g (1.9 mmol) 4-trifluoromethyloctanoic acid in 1 ml of dry diethyl ether was added dropwise thereto. The mixture was stirred for 4 hours on an ice bath for reaction, and a saturated sulfate aqueous solution was added thereto, followed by decantation to recover the ether layer. The ether solution was dried on sodium sulfate, followed by distilling-off of the solvent and distillation for purification to obtain 0.27 g of 4-trifluoromethyloctanol. Yield: 71%, B.P.: 80-85° C./19 mmHg.

Provenance & Evidence