Dimethyl Sulfoxide → Ethyl 4-(5-(tert-Butyl)-3-oxoisoxazol-2(3H)-yl)-3-nitrobenzoate

Participants

Reaction Steps

Ethyl-4-chloro-3-nitro-benzoate (413.3 grams), 305 grams of 5-t-butyl-3-hydroxyiso-oxazole and 1 liter of dimethylsulfoxide were mixed together and stirred. Next 300 grams of sodium bicarbonate were added and the mixture was reacted at 90° C. for a period of 8 hours. The reaction mixture was then cooled, 1.5 liter of methanol was added, followed by the addition of 3 liters of water, and the crystals which precipitated out were recovered by filtration.

Provenance & Evidence