Chloroform → HCID 15017604, compound

Participants

Reaction Conditions

Reaction Steps

In dry N,N-dimethylformamide was dissolved 6.0 g of 3-hydroxy-5H-benzofuro[3,2-c]quinolin-6-one, and 1.1 g of 2-dimethylaminoethyl chloride hydrochloride and 6.02 g of sodium bicarbonate were added to the solution. The mixture was stirred for 16 hours at 120° C. Into the reaction mixture were poured chloroform and water, and the insolved materials were filtered out. The organic layer was washed with water, dried over magnesium sulfate anhydride, and evaporated under reduced pressure. The residue was washed with ether, and recrystallized from chloroform and ethyl acetate to obtain 3.29 g of 3-(2-dimethylaminoethoxy)-5H-benzofuro[3,2-c]quinolin-6-one.

Provenance & Evidence