Formamide → HCID 18409955, compound

HRID 1460965Notes

Reaction equation

HRID 1460965 reaction equation
S(O)(O)(=O)=O.[NH2:6][C:7]1[N:8]=[C:9]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[O:21][CH2:22][CH2:23][CH3:24])[NH:10][C:11](=[O:14])[C:12]=1[NH2:13].S(=O)(=O)(O)O.[CH:30](N)=O>>[CH2:22]([O:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:9]1[N:8]=[C:7]2[C:12](=[N:13][CH:30]=[N:6]2)[C:11](=[O:14])[N:10]=1)[CH2:23][CH3:24]

Participants

4

Reactant 3

HCID 713FormamideHCID 1118Sulfuric AcidHCID 1363645694,5-Diamino-2-(propoxyphenyl)pyrimidin-6-one sulphate

Product 1

HCID 18409955HCID 18409955, compound

Procedure

A stirred mixture of 4,5-diamino-2-(2-propoxyphenyl)-pyrimidin-6-one sulphate (1.5 q) (prepared by the addition of concentrated sulphuric acid to an ethanolic solution of the free base) and formamide (15 ml) was heated in an oil bath (temp. 190°-200° C.) for 70 minutes. When cool the mixture was filtered and the collected solid was washed with ethanol to give a crude product (1.1 g), m.p. 254°-259° C., which was recrystallised from ethanol to give the title compound, 0.72 g, m.p. 263°-265° C.

Workup

  1. temperaturewas heated in an oil bath (temp. 190°-200° C.) for 70 minutes
  2. temperatureWhen cool the mixture
  3. filtrationwas filtered
  4. washthe collected solid was washed with ethanol
  5. customto give a crude product (1.1 g), m.p. 254°-259° C., which
  6. customwas recrystallised from ethanol

Sources & evidence

ORD record
ord-38c7efdbee2744b9bd37b4829a660ef7
Source dataset
uspto-grants-1991_12
Patent number
US05073559

Reaction notes

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