Formamide → HCID 21250837, compound

HRID 1460966Notes

Reaction equation

HRID 1460966 reaction equation
S(O)(O)(=O)=O.[NH2:6][C:7]1[N:8]=[C:9]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[O:21][CH2:22][CH:23]2[CH2:25][CH2:24]2)[NH:10][C:11](=[O:14])[C:12]=1[NH2:13].[CH:26](N)=O>>[CH:23]1([CH2:22][O:21][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=2[C:9]2[N:8]=[C:7]3[C:12](=[N:13][CH:26]=[N:6]3)[C:11](=[O:14])[N:10]=2)[CH2:24][CH2:25]1

Participants

3

Reactant 2

HCID 713FormamideHCID 136341209HCID 136341209, compound

Product 1

HCID 21250837HCID 21250837, compound

Conditions

Temperature
180 °C

Procedure

A stirred mixture of 4,5-diamino-2-(2-cyclopropylmethoxyphenyl)pyrimidin-6-one sulphate (1.48 g) and formamide (5 ml) was heated in an oil bath at 180° C. for 2 to 3 hours. The cooled mixture was filtered and the collected solid was washed with ethanol to give a crude product (1.07 g) which was recrystallised three times from ethanol to afford the title compound, 0.32 g, m.p. 259°-260° C.

Workup

  1. filtrationThe cooled mixture was filtered
  2. washthe collected solid was washed with ethanol
  3. customto give a crude product (1.07 g) which
  4. customwas recrystallised three times from ethanol

Sources & evidence

ORD record
ord-7c5e6c26f0a041238a02fafe54a8c659
Source dataset
uspto-grants-1991_12
Patent number
US05073559

Reaction notes

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