反应详情

A mixture of 4,5-diamino-2-(2-propoxyphenyl)-pyrimidine-6-one (1.3 g), benzamidine hydrochloride (2 g) and anhydrous sodium acetate (0.9 g) was heated in an oil bath (temperature 160°-170° C.) for 2 hours. The reaction mixture was digested with hot ethanol to give a solid, 0.76 g, m.p. 267°-271° C. This was combined with a further sample, 0.2 g, (similarly prepared) and recrystallised from aqueous acetic acid to give the title compound, 0.74 g, m.p. 259°-260° C.

1. temperaturewas heated in an oil bath (temperature 160°-170° C.) for 2 hours
2. customto give a solid, 0.76 g, m.p. 267°-271° C
3. custom(similarly prepared) and
4. customrecrystallised from aqueous acetic acid