Acetamidine monohydrochloride → 2-(2-Propoxyphenyl)-8-methylpurin-6-one

HRID 1460968Notes

Reaction equation

HRID 1460968 reaction equation
[NH2:1][C:2]1[N:3]=[C:4]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][CH2:17][CH2:18][CH3:19])[NH:5][C:6](=[O:9])[C:7]=1[NH2:8].[C:20]([O-])(=O)[CH3:21].[Na+].Cl.C(N)(=N)C>C(O)C>[CH2:17]([O:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[C:4]1[N:3]=[C:2]2[C:7](=[N:8][C:20]([CH3:21])=[N:1]2)[C:6](=[O:9])[N:5]=1)[CH2:18][CH3:19]

Participants

5

Reactant 3

HCID 67170Acetamidine monohydrochlorideHCID 517045Sodium AcetateHCID 1357098565,6-Diamino-2-(2-propoxyphenyl)pyrimidin-4(3H)-one

Product 1

HCID 212506972-(2-Propoxyphenyl)-8-methylpurin-6-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4,5-diamino-2-(2-propoxyphenyl)pyrimidin-6-one (1.56 g), anhydrous sodium acetate (114 g) and acetamidine hydrochloride (142 g) was heated in an oil bath at 150°-160° C. for 2 hours. The mixture was digested with ethanol (2 ml), cooled, filtered and the solid washed with ethanol. Recrystallisation from ethanol gave the title compound, 0.72 g, m.p. 264°-265° C.

Workup

  1. temperaturewas heated in an oil bath at 150°-160° C. for 2 hours
  2. temperaturecooled
  3. filtrationfiltered
  4. washthe solid washed with ethanol
  5. customRecrystallisation from ethanol

Sources & evidence

ORD record
ord-2e5e8045d3844c47ad5eab97a41d90cb
Source dataset
uspto-grants-1991_12
Patent number
US05073559

Reaction notes

Loading…