反应详情

A mixture of 4,5-diamino-2-(2-propoxyphenyl)pyrimidin-6-one (1.56 g), anhydrous sodium acetate (114 g) and acetamidine hydrochloride (142 g) was heated in an oil bath at 150°-160° C. for 2 hours. The mixture was digested with ethanol (2 ml), cooled, filtered and the solid washed with ethanol. Recrystallisation from ethanol gave the title compound, 0.72 g, m.p. 264°-265° C.

1. temperaturewas heated in an oil bath at 150°-160° C. for 2 hours
2. temperaturecooled
3. filtrationfiltered
4. washthe solid washed with ethanol
5. customRecrystallisation from ethanol