Ammonia → 2-(2-Propoxy-5-sulphamoylphenyl)purin-6-one

Participants

Reaction Steps

In a similar manner to Example 18 reaction of 2-(2-propoxyphenyl)purin-6-one (0.95 g) with chlorosulphonic acid (4.5 ml), followed by reaction with saturated methanolic ammonia (50 ml), yielded a crude product (0.92 g) which was recrystallised from aqueous ethanol and then from dimethylformamide to yield the pure title compound, 0.59 g, m.p. 276°-278° C.

Provenance & Evidence