Benzylamine → HCID 18985341, compound

HRID 1461045Notes

Reaction equation

HRID 1461045 reaction equation
[CH2:1]([CH:3]1[O:5][CH2:4]1)[F:2].[CH2:6]([NH2:13])[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>C(O)C>[F:2][CH2:1][CH:3]([OH:5])[CH2:4][N:13]([CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[CH2:4][CH:3]([OH:5])[CH2:1][F:2]

Participants

4

Reactant 2

HCID 7504BenzylamineHCID 104181,2-Epoxy-3-fluoropropane

Product 1

HCID 18985341HCID 18985341, compoundYield 100.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 27.28 g (0.359 mole) of epifluorohydrin and 19.20 g (0.1795 mole) of benzylamine dissolved in 200 ml of ethanol was heated under reflux for 4 hours. The reaction mixture was then concentrated by evaporation under reduced pressure, to give 46.6 g of N,N-bis(3-fluoro-2-hydroxypropyl)benzylamine as a colorless oil.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 4 hours
  3. concentrationThe reaction mixture was then concentrated by evaporation under reduced pressure

Sources & evidence

ORD record
ord-2edfbc54e6064c9eb69b64711a81fd72
Source dataset
uspto-grants-1991_12
Patent number
US05073556

Reaction notes

Loading…