HCID 178498896, compound → HCID 178429728, compound

HRID 1461069Notes

Reaction equation

HRID 1461069 reaction equation
[SH:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[CH:10][C:11]([C:12]([O:14]C)=[O:13])=[C:4]2[N:3]=1>[OH-].[Na+]>[SH:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[CH:10][C:11]([C:12]([OH:14])=[O:13])=[C:4]2[N:3]=1

Participants

3

Reactant 1

HCID 178498896HCID 178498896, compound

Product 1

HCID 178429728HCID 178429728, compound

Reagents, catalysts & solvents 1

HCID 14798Sodium HydroxideSolvent

Procedure

7.20 g of methyl 5-mercapto-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylate were heated to 100° in 2N sodium hydroxide solution until almost all had dissolved. The solution was cooled, filtered and the filtrate was adjusted to pH 2. The product was filtered off under suction, washed with water and acetone and dried. There was obtained 5-mercapto-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid of m.p. 225° (dec.).

Workup

  1. dissolutionall had dissolved
  2. temperatureThe solution was cooled
  3. filtrationfiltered
  4. filtrationThe product was filtered off under suction
  5. washwashed with water and acetone
  6. customdried

Sources & evidence

ORD record
ord-f2563e468d5c4380a6e09e2f0b46d18f
Source dataset
uspto-grants-1991_12
Patent number
US05073550

Reaction notes

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