HCID 178429728, compound → HCID 178429727, compound

HRID 1461070Notes

Reaction equation

HRID 1461070 reaction equation
[SH:1][C:2]1[CH:7]=[C:6]([CH3:8])[N:5]2[N:9]=[CH:10][C:11](C(O)=O)=[C:4]2[N:3]=1>C(=O)([O-])O.[K+]>[CH3:8][C:6]1[N:5]2[N:9]=[CH:10][CH:11]=[C:4]2[N:3]=[C:2]([SH:1])[CH:7]=1

Participants

3

Reactant 1

HCID 178429728HCID 178429728, compound

Product 1

HCID 178429727HCID 178429727, compound

Reagents, catalysts & solvents 1

HCID 516893Potassium BicarbonateSolvent

Procedure

2.00 g of 5-mercapto-7-methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid were heated to 220° under argon for 1 hour. After cooling, the reaction mixture was taken up in 10 percent potassium hydrogen carbonate solution. The insoluble portion was filtered off under suction and taken up in water. The solution was acidified to pH 2 and the precipitate was filtered off under suction. After drying, there was obtained 7-methylpyrazolo[1,5-a]pyrimidine-5-thiol.

Workup

  1. temperatureAfter cooling
  2. filtrationThe insoluble portion was filtered off under suction
  3. filtrationthe precipitate was filtered off under suction
  4. customAfter drying

Sources & evidence

ORD record
ord-2e67143ff3924133b484d0fa576c70be
Source dataset
uspto-grants-1991_12
Patent number
US05073550

Reaction notes

Loading…