HCID 54045152, compound → HCID 54511231, compound

HRID 1461101Notes

Reaction equation

HRID 1461101 reaction equation
[CH2:1]([O:3][C:4](=[O:34])[CH:5]([CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[N:6]1[CH:10]=[C:9]([NH:11][C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([N+:20]([O-])=O)[C:15]=2[C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:13])[N:8]=[CH:7]1)[CH3:2]>[Pd]>[CH2:1]([O:3][C:4](=[O:34])[CH:5]([CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH3:33])[N:6]1[CH:10]=[C:9]([NH:11][C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([NH2:20])[C:15]=2[C:23]([O:25][CH2:26][CH3:27])=[O:24])=[O:13])[N:8]=[CH:7]1)[CH3:2]

Participants

3

Reactant 1

HCID 54045152HCID 54045152, compound

Product 1

HCID 54511231HCID 54511231, compoundYield 98.4%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 5.1 g of α-hexyl-4-{[(3-nitro-2-ethoxycarbonylphenyl)carbonyl]amino}imidazole-1-acetic acid ethyl ester and 2.1 g of 5% palladium-on-carbon were hydrogenated in the presence of 150 ml of methanol until consumption of hydrogen ceased. The catalyst was removed by filtration and the filtrate concentrated in vacuo to provide 4.7 g of the desired subtitled intermediate. NMR.

Workup

  1. customwere hydrogenated in the presence of 150 ml of methanol until consumption of hydrogen
  2. customThe catalyst was removed by filtration
  3. concentrationthe filtrate concentrated in vacuo

Sources & evidence

ORD record
ord-2ef4a1a35a1f4f938a56c483ff714328
Source dataset
uspto-grants-1991_12
Patent number
US05073566

Reaction notes

Loading…