反应详情

A mixture of (benzoyloxy)acetyl chloride (1.98 g, 0.01 mole), pyrrolidone (0.85 g, 0.01 mole) and pyridine (0.8 g, 0.01 mole) in acetone (10 ml) was refluxed for 3 h. The cooled mixture was filtered and evaporated in vacuo. The residue was dissolved in ethyl acetate (50 ml) and the solution washed with a 2% aqueous solution of sodium bicarbonate, 2M hydrochloric acid and water. After drying over anhydrous sulphate, the organic phase was evaporated under reduced pressure to give a residue which crystallized by addition of ether. Recrystallization from ether-petroleum ether yielded 1.6 g (65%) of the title compound. Mp 83°-84° C.

1. temperaturewas refluxed for 3 h
2. filtrationThe cooled mixture was filtered
3. customevaporated in vacuo
4. dissolutionThe residue was dissolved in ethyl acetate (50 ml)
5. washthe solution washed with a 2% aqueous solution of sodium bicarbonate, 2M hydrochloric acid and water
6. dry with materialAfter drying over anhydrous sulphate
7. customthe organic phase was evaporated under reduced pressure
8. customto give a residue which
9. customcrystallized by addition of ether
10. customRecrystallization from ether-petroleum ether