2-chloro-N,N-dimethylacetamide → HCID 13096286, compound

HRID 1461125Notes

Reaction equation

HRID 1461125 reaction equation
[C:1]([O-:4])(=[O:3])[CH3:2].[Na+].Cl[CH2:7][C:8]([N:10]([CH3:12])[CH3:11])=[O:9]>C1(C)C=CC=CC=1>[C:1]([O:4][CH2:7][C:8]([N:10]([CH3:12])[CH3:11])=[O:9])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 758862-chloro-N,N-dimethylacetamideHCID 517045Sodium Acetate

Product 1

HCID 13096286HCID 13096286, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A suspension of anhydrous sodium acetate (16.4 g, 0.2 mole) and 2-chloro-N,N-dimethylacetamide (24.3 g, 0.2 mole) in toluene (70 ml) was refluxed for 4 h. After cooling to room temperature the mixture was filtered and the filtrate washed with water (2×10 ml), dried and evaporated in vacuo. The solid residue obtained was recrystallized from ether yielding 22.0 g (76%). Mp 52°-53° C.

Workup

  1. temperaturewas refluxed for 4 h
  2. filtrationwas filtered
  3. washthe filtrate washed with water (2×10 ml)
  4. customdried
  5. customevaporated in vacuo
  6. customThe solid residue obtained
  7. customwas recrystallized from ether yielding 22.0 g (76%)

Sources & evidence

ORD record
ord-763b3bbc1d0f4399b570c22477aca16a
Source dataset
uspto-grants-1991_12
Patent number
US05073641

Reaction notes

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