Lithium Hydroxide → HCID 11756030, compound

Participants

Reaction Steps

The compound of Example 4 (25 mg, 47.7 μmol) along with 1.0 ml of 4:I methanol/THF, and 0.09 ml of 1 N lithium hydroxide were stirred at 0° C. for thirty minutes. An additional 0.09 ml of 1 N lithium hydroxide was added and the reaction mixture was stirred at room temperature for 45 minutes. The reaction mixture was poured into 0.5 N hydrochloric acid/ethyl acetate. The ethyl acetate layer was washed with brine, dried over sodium sulfate, and concentrated under Vacuum to give the product; melting point 136-139° C. High resolution mass spectrum m/e 510.2471 (calculated for C29H36NO7 (M+H), 510.2492).

Provenance & Evidence