Lithium Hydroxide → HCID 10347709, compound

Participants

Reaction Steps

The compound of Example 25 (47 mg, 82.2 μmol) was added to 2.5 ml of 4:1 methanol/THF, and 0.2 ml of 1 N lithium hydroxide was added. The mixture was allowed to react at room temperature for 2.5 hours. The reaction mixture was poured into ethyl acetate/water and the ethyl acetate was washed with brine, dried over sodium sulfate and concentrated. Flash chromatography of the residue of silica gel using 7:1 to 5:1 hexane/ethyl acetate (1% acetic acid) as eluant gave the product, melting point 149- 51° C., (44 mg, 79 μmol, 96% yield). High resolution mass spectrum, m/e 557.1895 (calculated for C29H5NO6S2, 557.1906).

Provenance & Evidence