Hydrochloric Acid → HCID 14621694, compound

Participants

Reaction Steps

The said ester (0.6 g, 1.3 mmol) was dissolved in methanol (10 ml). By addition of concentrated hydrochloric acid (0.1 ml) it was stirred at room temperature for 2 hours. After the solvent was distilled off, a small amount of water was added to the residue and aqueous saturated sodium bicarbonate solution was added to adjust to pH 8-9. It was dissolved by addition of ethyl acetate and the oganic layer was separated. The organic layer was dried and the solvent was dissolved off, and the residue was purified by silica gel column chromatography thereby p-methoxybenzyl 7-amino-3-[(Z)-2-(1,2,3-thiadiazol-4-yl)vinyl]-3-cephem-4-carboxylate (0.21 g) was obtained as a yellow powder solid.

Provenance & Evidence