Formic Acid → HCID 88523025, compound

Participants

Reaction Steps

Benzhydryl 7-[(Z)-2-(2-tritylaminothiazol-4-yl)-2-trityloxyiminoacetamido]-3-[(Z)-2-(5-methyl-1,2,3-thiadiazol-4-yl)vinyl]-3-cephem-4-carboxylate (0.5 g, 0.4 mmol) was stirred at room temperature for 2 hours by addition of formic acid (5 ml). Concentrated hydrochloric acid (40 μl) was added to the reaction solution and it was stirred at room temperature for 1 hour. The reaction solution was concentrated under reduced pressure and then the residue was cleansed with ether thereby a powdered product was obtained. This one was dissolved in aqueous sodium bicarbonate solution and purified by HP-20 column chromatography thereby sodium 7-[(Z)-2-(2-aminothiazol-4-yl)-2-hydroxyiminoacetamido]-3-[(Z)-2-(5-methyl-1,2,3-thiadiazol-4-yl)vinyl]-3-cephem-4-carboxylate (0.13 g) was obtained.

Provenance & Evidence