Thionyl Chloride → 3-(2-Thienyl)acryloylchloride

HRID 1461189Notes

Reaction equation

HRID 1461189 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([OH:10])=O.S(Cl)([Cl:13])=O>C1C=CC=CC=1>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([Cl:13])=[O:10]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 928683-Thiophen-2-ylprop-2-enoic acid

Product 1

HCID 534112883-(2-Thienyl)acryloylchloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

65 ml of benzene was added to 10 grams of 3-(2-thienyl)acrylic acid. 7.8 ml of thionyl chloride was added dropwise slowly thereto at ambient temperature. The temperature was elevated to 70° C. and the heating was continued until foaming ceased. Benzene and thionyl chloride were distilled off and the residue was dried thoroughly under reduced pressure.

Workup

  1. customat ambient temperature
  2. customwas elevated to 70° C.
  3. distillationBenzene and thionyl chloride were distilled off
  4. customthe residue was dried thoroughly under reduced pressure

Sources & evidence

ORD record
ord-2a87550c31b64cd28d0db98b7cd50715
Source dataset
uspto-grants-1991_12
Patent number
US05075009

Reaction notes

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