Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Lithium borohydride → (S)-tert-Butyl 4-((tert-butoxycarbonyl)amino)-5-hydroxypentanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Lithium borohydride | HCID 4148881 | — |
| 반응물 | (4S)-5-(tert-butoxy)-4-{[(tert-butoxy)carbonyl]amino}-5-oxopentanoic acid | HCID 6993444 | — |
| 반응물 | Z-Glu-OtBu | HCID 6994036 | — |
| 생성물 | (S)-tert-Butyl 4-((tert-butoxycarbonyl)amino)-5-hydroxypentanoate | HCID 4055117 | — |
반응 단계
Cbz-Glu-OtBu 51 is converted to 52 via the methyl ester followed by LiBH4 reduction according to the procedure of Y. Hamada, M. Shibata, T. Sugiura, S. Kato and T. Shioiri, J. Org. Chem. 52:1242, 1987 used for the conversion of t-Boc-Glu-OtBu to the corresponding alcohol.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05075099 |
| 출처 데이터셋 | uspto-grants-1991_12 |
| ORD ID | ord-676b5c03cf8344c3bcce50d3fa8a5cf6 |
| 출처 메모 | uspto-grants-1991_12 |