Sorbitol → Phenylpropanolamine hydrochloride Sorbitol

Participants

Reaction Steps

Once thoroughly dispersed, the molten sorbitol melt containing uniformly dispersed particles of phenylpropanolamine hydrochloride was placed in a jacketed agitator equipped with double Sigma blades and slowly cooled to 90° C. with a steam/water mix flowing through the jacket and maintaining constant agitation, until the molten magma was crystallized to a viscous mass. At this point, such viscous mass was transferred to trays and held in an oven at 90° C. for 4 hours until it was fully crystallized. Lumps of this fully crystallized material were ground in a Waring blender and screened through a set of stainless steel screens collecting the material passing through the 40 mesh (U.S. Sieve Series) screen and held on a 100 mesh screen (-40/+100 cut). The resultant powder was assayed and was found to contain 3.8% phenylpropanolamine hydrochloride.

Provenance & Evidence