Ibuprofen, (+-)- → HCID 86745308, compound

Participants

Reaction Conditions

Reaction Steps

950 parts of a sorbitol were heated in a stainless steel mixer to 110° and then slowly cooled under high speed agitation to 75° C. and maintained at that temperature. 50 parts of ibuprofen (mp 75°-77° C.) were added very slowly to the vortex to ensure a homogenous distribution. After mixing for 10 minutes, the melt containing 5% ibuprofen was transferred to a Sigma blade mixer and the temperature maintained at 74° C., while agitation continued for 20 minutes at a rotation speed of 30 r.p.m. until the mixture partially crystallized. The partially solidified mass was removed from the mixer and placed on a tray to allow it to crystallize fully while held at a temperature of 50° C. for 12 hours. The material was cooled and ground and screened to produce a particle size distribution of -40/+100.

Provenance & Evidence