Potassium Carbonate → HCID 19980215, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of 5 g of 6-methyl-5-hydroxy-2-hydroxy-4-pyrone in 60 ml of dimethylformamide were successively added 6.8 g of potassium carbonate and 6.2 g of p-methoxybenzyl chloride. The mixture was stirred at 60° C. for 6 hours. After the reaction mixture was concentrated, 200 ml of water and 400 ml of dichloromethane were added to the concentrate. The organic phase was washed with 200 ml of water. After drying over anhydrous magnesium sulfate, the organic phase was concentrated under reduced pressure. The concentrate was separated and purified by flash column chromatography (eluting solution; chloroform: methanol=20:1) using Wako Gel C-300 (manufactured by Wako Pure Chemical Industry Co., Ltd.) (100 g) to give 5.3 g of the title compound.

Provenance & Evidence