Potassium Carbonate → HCID 19980210, compound

Participants

Reaction Steps

To a solution of 1 g of 6 methyl-5-p-methoxybenzyloxy-2-hydroxymethyl-1-hydroxy-4-pyridone in 60 ml of dimethylformamide were successively added 710 mg of potassium carbonate and 1.3 g of diphenylmethyl bromide. The mixture was stirred at room temperature for 17 hours. After completion of the reaction, the reaction liquid was concentrated and the concentrate was added to 20 ml of water and 40 ml of dichloromethane. The organic phase was washed with 20 ml of water. After drying over anhydrous magnesium sulfate, the organic phase was concentrated under reduced pressure. The concentrate was separated and purified by flash column chromatography (eluting solution; chloroform: methanol=20:1) using Wako Gel C-300 (100 g) to give 1.35 g of the title compound.

Provenance & Evidence