Formaldehyde → 3-hydroxy-6-(hydroxymethyl)-2-(morpholinomethyl)-4H-pyran-4-one

HRID 1461246Notes

Reaction equation

HRID 1461246 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH2:7]=O.[CH:9]1[C:14](=[O:15])[C:13]([OH:16])=[CH:12][O:11][C:10]=1[CH2:17][OH:18]>C(O)C>[O:4]1[CH2:5][CH2:6][N:1]([CH2:7][C:12]2[O:11][C:10]([CH2:17][OH:18])=[CH:9][C:14](=[O:15])[C:13]=2[OH:16])[CH2:2][CH2:3]1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 3840Kojic AcidHCID 8083Morpholine

Product 1

HCID 2616163-hydroxy-6-(hydroxymethyl)-2-(morpholinomethyl)-4H-pyran-4-one

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In 70 ml of ethanol were dissolved 7 g of morpholine and 6.4 ml of 35% formalin followed by stirring at room temperature for 30 minutes. Further, 8.3 g of kojic acid was added thereto and stirred for 30 minutes in the same temperature. The formed crystals were taken out by filtration, washed in succession with ethanol and ether and dried to give 11.5 g of the title compound.

Workup

  1. stirringstirred for 30 minutes in the same temperature
  2. filtrationThe formed crystals were taken out by filtration
  3. washwashed in succession with ethanol and ether
  4. customdried

Sources & evidence

ORD record
ord-a161c371c998447fafe5bd3bda6d8100
Source dataset
uspto-grants-1991_12
Patent number
US05075299

Reaction notes

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