HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 11856575, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Acetylthiomethyl-3-phenyl-propionyl chloride | HCID 10377734 | — |
| Reactant | (S)-4-Aminoazepan-2-one | HCID 18603542 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 11856575 | HCID 11856575 | — |
Reaction Steps
Combine 3(S)-amino-ε-caprolactam (1.00 g, 7.8 mmol) and triethylamine (0.87 g, 8.6 mmol) in acetonitrile (40ml) and H2O (20 ml). Add dropwise 2-acetylthiomethyl-3-phenylpropionyl chloride. After 30 min, add 1.0N HCl (13 ml), extract with ethyl acetate (EtOAc), dry and concentrate. Chromatograph on silica, eluting with 3%MeOH/CH2Cl2 to obtain the title compound as a foam. MS: M+1=349.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05075302 |
| Source dataset | uspto-grants-1991_12 |
| ORD ID | ord-abd8c7d873d240f08481e4617990aa03 |
| Source note | uspto-grants-1991_12 |