反应详情

A solution of N-ethoxalyl-4-chloro-2-trifluoromethylaniline in concentrated sulphuric acid (125 ml) was added to a stirred mixture of 100% nitric acid (120 ml) and concentrated sulphuric acid (240 ml). The temperature was kept between 8°-10° C. during the addition. After the addition was completed, the solution was stirred for additionally 20 min. without external cooling, whereafter it was poured onto icewater. This afforded precipitation of the title compound as an oil, which crystallized as light yellow crystals upon standing. The crystals were filtered off and washed extensively with water. M.p. 100°-101° C.

1. additionThe temperature was kept between 8°-10° C. during the addition
2. additionAfter the addition
3. additionwas poured onto icewater
4. customThis afforded precipitation of the title compound as an oil, which
5. customcrystallized as light yellow crystals
6. filtrationThe crystals were filtered off
7. washwashed extensively with water