Acetic Acid → HCID 15675405, compound

Participants

Reaction Steps

In 30 ml of piperidine was dissolved 7.4 g (29.25 mmol) of Compound s followed by addition of 2.7 g (45 mmol) of acetic acid, and the mixture was heated under reflux for 27 hours. After cooling, the excess piperidine was distilled off under reduced pressure and the residue was diluted with 300 ml of chloroform and washed with 3 portions of saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous magnesium sulfate and the solvent was distilled off under reduced pressure. Finally the residue was purified by silica gel column chromatography (acetone) to give 6.49 g (76.0%) of 1-[5-(4-hydroxypiperidinomethyl)-2-furancarbonyl]piperidine (Compound t) as light yellow oil.

Provenance & Evidence