Methane → HCID 70240816, compound

Participants

Reaction Conditions

Reaction Steps

A stirred mixture of 2-propoxybenzamidine methanesulphonate (1.0 g), 3-amino-4-pyrazolecarboxamide sulphate (0.5 g) and sodium acetate (0.82 g) was heated in an oil bath (180° C.) for one hour. The reaction mixture was dissolved in hot 2 Normal sodium hydroxide (10 ml) and the solution was treated with charcoal and neutralised with glacial acetic acid. A precipitate was collected, washed with water and eluted from a silica column with chloroform. The combined fractions containing product were evaporated to dryness to afford the title compound, 148 mg, m.p. 182°-183.5° C.

Provenance & Evidence