反应详情

10.1 g (0.105 mol) of ammonium carbonate are added to a solution of 19.9 g (0.1 mol) of 2,4-dichloro-5-nitrothiazole in 200 ml of acetonitrile, while stirring, and stirring is continued at room temperature for two days. The mixture is then stirred into 1 l of ice-water and the precipitate is filtered off, washed with water and dried. To remove unreacted 2,4-dichloro-5-nitrothiazole, the product is stirred into about 100 ml of petroleum ether at room temperature, filtered off, washed with petroleum ether and dried. 12.2 g (68.0% of theory) of 2-amino-4-chloro-5-nitrothiazole of melting point 180° C. (decomposition) are obtained.

1. stirringstirring
2. filtrationthe precipitate is filtered off
3. washwashed with water
4. customdried
5. customTo remove unreacted 2,4-dichloro-5-nitrothiazole
6. stirringthe product is stirred into about 100 ml of petroleum ether at room temperature
7. filtrationfiltered off
8. washwashed with petroleum ether
9. customdried