2-(Bromomethyl)-5-(trifluoromethyl)furan → 1'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[5,6-dihydro-2H-furo[3,2-f][1]benzofuran-3,3'-indole]-2'-one

HRID 146144Notes

Reaction equation

HRID 146144 reaction equation
[Br:43][CH2:44][c:45]1[o:46][c:47]([C:50]([F:51])([F:52])[F:53])[cH:48][cH:49]1.[Cl:54][CH2:55][c:56]1[cH:57][n:58][c:59]([O:60][CH3:61])[n:62][cH:63]1.[NH:1]1[C:2](=[O:21])[C:3]2([c:4]3[c:5]([cH:8][c:9]4[c:13]([cH:14]3)[CH2:12][CH2:11][O:10]4)[O:6][CH2:7]2)[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]21.[NH:22]1[c:23]2[c:24]([cH:25][cH:26][cH:27][cH:28]2)[C:29]2([CH2:30][O:31][c:32]3[cH:33][c:34]4[c:35]([cH:36][c:37]32)[CH2:38][CH2:39][O:40]4)[C:41]1=[O:42]>>[N:1]1([CH2:44][c:45]2[o:46][c:47]([C:50]([F:51])([F:52])[F:53])[cH:48][cH:49]2)[C:2](=[O:21])[C:3]2([c:4]3[c:5]([cH:8][c:9]4[c:13]([cH:14]3)[CH2:12][CH2:11][O:10]4)[O:6][CH2:7]2)[c:15]2[cH:16][cH:17][cH:18][cH:19][c:20]21

Participants

4

Reactant 3

HCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 216981735-(Chloromethyl)-2-methoxypyrimidineHCID 592633545,6-dihydro-2H-spiro[benzofuro[6,5-b]furan-3,3'-indolin]-2'-one2×

Product 1

HCID 592633761'-[[5-(trifluoromethyl)furan-2-yl]methyl]spiro[5,6-dihydro-2H-furo[3,2-f][1]benzofuran-3,3'-indole]-2'-one

Sources & evidence

ORD record
ord-28fbeeead5014a38b40fce898fb19193
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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